Our previous research has shown that older women often have placentas that aren’t working as well as they should. These changes are related to the ageing process.
What we don’t currently know is whether these ageing-related changes are due to older eggs, or due to changes to the mother’s blood vessels or metabolism.
To investigate this, we will be studying pregnancy in older mice. We will be looking at whether the same effects are seen when older mice are impregnated with eggs from younger mice.
This project aims to close the gaps in our knowledge of the ageing placenta in pregnancy outcomes.
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