Tommy's trials at multiple hospitals
We are investigating whether anti-coagulant (blood thinning) treatment could reduce the risk of miscarriage in women aged 18 to 42 years, with two or more previous miscarriages and with inherited thrombophilia. Thrombophilia is when your blood has a tendency to clot more than normal. Please email [email protected] to register your interest in taking part in this research at Birmingham Women's Hospital. To register your interest in taking part at University Hospital Coventry, please ring 0247 6964 983 to speak to the clinic secretary about your interest in this research. Your eligibility for the study will be assessed and if you are eligible you will be given further information about how to take part.
We are investigating whether a single drug treatment (misoprostol) or a combination of drug treatments (mifepristone plus misoprostol two days later) is best for the medical management of missed miscarriage. To be eligible for the study women must: be diagnosed with a missed miscarriage by pelvic ultrasound scan in the first 13+6 weeks of pregnancy, be opting for medical management, be 16 years of age or over and be willing and able to give informed consent.
Please note, this trial is being conducted at several hospitals across the UK. Therefore, if you are not local to Birmingham, there might be a hospital closer to where you live that is offering this trial. Please email [email protected] to register your interest in taking part in this research.
Tommy's trials at Birmingham Women's Hospital
This project investigates whether analysis of cell-free fetal DNA could help us to ascertain genetic reasons for early miscarriages. Women with a diagnosis of recurrent miscarriage, threatened miscarriage, missed miscarriage or incomplete miscarriage are eligible to participate in the study. Please email [email protected] to register your interest in taking part in this research at this hospital.
This project investigates whether miscarriage could be caused by sperm DNA damage in the male partner of couples having investigations for recurrent miscarriage. Please email [email protected] to register your interest in taking part in this research at this hospital.
We are investigating whether adaptations of the maternal immune system could be implicated in patients with a history of recurrent miscarriage. Please email [email protected] to register your interest in taking part in this research at this hospital.
Tommy's trials at University Hospital Coventry
We are investigating whether scratching the lining of the womb could prevent miscarriage among women aged 18 to 42 years and with two or more previous miscarriages. Please telephone 0247 6964 983 to speak to the clinic secretary about your interest in this research.
Tommy's trials at Imperial College London
We are investigating if it is possible to look in detail at your baby’s heart, brain, spinal cord, bones, kidneys and stomach before 18 weeks of pregnancy using new ultrasound techniques and 3D ultrasound scanning. We will perform 2 extra ultrasound scans of your baby between 12 and 18 weeks of pregnancy. To be eligible for the study participants must be aged over 18 years and more than 7 weeks pregnant. Please email [email protected] or ring 07518210305 to register your interest in taking part in this research.
The early pregnancy period is critical for pregnancy success. We are investigating the impact of early pregnancy events such as pain and bleeding on the future risk of miscarriage and risk of long-term pregnancy complications such as pre-eclampsia and preterm labour. Women who are less than 14 weeks pregnant, aged between 16 and 50 years, with or without the pregnancy events described, are eligible to participate in the study. Participants are seen up to six times during their pregnancy where ultrasound scans are performed, and samples collected to screen for differences between women who do and do not have adverse pregnancy outcomes. For more information about the study, please email [email protected] or call the clinical research fellow on 07934920180.
It has been realised that there are bacteria in all parts of our body and the word microbiome refers to the genetic material of these organisms. Currently it is not known whether an imbalance of this bacteria or the presence of a certain type is linked to miscarriage. We are investigating whether there is a normal early pregnancy and endometrial microbiome, and whether this changes in miscarriage. We are also looking to identify a better way to see if someone has miscarried because of a chromosomal issue. Those undergoing management of the miscarriage will have the tissue analysed for chromosome abnormalities and are welcome to receive the results if they wish. Please email [email protected] or ring 0203 303 5131 if you would like to find out more information.
In a recent pilot study published in BMJ Open we showed that women who have miscarried or had an ectopic pregnancy have high levels of post-traumatic stress disorder (PTSD) as well as anxiety and depression. We are currently analysing the data from the full study examining the psychological impact of early pregnancy events on both women and their partners. Our next study will be to examine the value of different treatment strategies to help women deal with the psychological consequences of early pregnancy loss.
‘PUL’ (pregnancy of unknown location) is a phenomenon in early pregnancy where a woman has a positive pregnancy test but we cannot see where the pregnancy is with an ultrasound scan. The majority of women in this situation will sadly be undergoing a very early miscarriage but some will go onto have a healthy pregnancy. There is a period of uncertainty whilst the outcome of the pregnancy is determined. We are carrying out research that may help come to a diagnosis much earlier to better support women and their partners through what is an emotionally demanding time. If you would like more information, please contact [email protected]
We are investigating if maternal cardiovascular function prior to pregnancy, and also an adaptation of the mum’s heart and circulation to pregnancy impacts on pregnancy outcomes, specifically first trimester miscarriage, pre-eclampsia and fetal growth restriction. We have therefore been recruiting women pre-conception, and following them through pregnancy to the post-partum period with comprehensive cardiovascular investigations. This study is now closed for recruitment, but for further information, please email [email protected] or visit our facebook page https://www.facebook.com/conceivestudy/