Tommy's trials at multiple hospitals
In some women the lining of the womb (the endometrium) is inflamed (a condition called endometritis), and researchers have found a link between this and miscarriage. Treating endometritis with antibiotics may reduce the inflammation and the likelihood of a miscarriage. In this trial, we are trying to find out if taking a short course of antibiotics can reduce the risk of miscarriage by comparing it with a placebo.
The CERM trial is currently running at multiple locations in the UK. If you are aged between 18 and 42, have experienced 2 or more early miscarriages in a row and your losses are unexplained, you may be able to take part in this study. For more information, visit the CERM trial website or email [email protected].
Tommy's trials in London
The early pregnancy period is critical for pregnancy success. We are investigating the impact of early pregnancy events such as pain and bleeding on the future risk of miscarriage and risk of long-term pregnancy complications such as pre-eclampsia and preterm labour. Women who are less than 14 weeks pregnant, aged between 16 and 50 years, with or without the pregnancy events described, are eligible to participate in the study. Participants are seen up to six times during their pregnancy where ultrasound scans are performed, and samples collected to screen for differences between women who do and do not have adverse pregnancy outcomes. For more information about the study, please email [email protected] or call the clinical research fellow on 07934920180.
It has been realised that there are bacteria in all parts of our body and the word microbiome refers to the genetic material of these organisms. Currently it is not known whether an imbalance of this bacteria or the presence of a certain type is linked to miscarriage. We are investigating whether there is a normal early pregnancy and endometrial microbiome, and whether this changes in miscarriage. We are also looking to identify a better way to see if someone has miscarried because of a chromosomal issue. Those undergoing management of the miscarriage will have the tissue analysed for chromosome abnormalities and are welcome to receive the results if they wish. Please email [email protected] or ring 0203 303 5131 if you would like to find out more information.
Tommy's trials in Birmingham
This project investigates whether miscarriage could be caused by sperm DNA damage in the male partner of couples having investigations for recurrent miscarriage. For more information on taking part, please email [email protected] or [email protected].