The Tommy’s national miscarriage trial platform

With more than 90 hospitals already involved, Tommy’s are growing a network of researchers and doctors who can work together to carry out clinical trials that may lead to new treatments for miscarriage.
  • Author's list

    Professor Arri Coomarasamy, Dr Adam Devall, Professor Siobhan Quenby, Rajinder Kaur

    Start date: 2016
    End date: 2026

Why do we need this research?

Around 1 in 5 women will have a miscarriage in their lifetime. However, we still don’t have effective ways to predict miscarriage or to prevent it from happening.

In order to test new treatments that could prevent miscarriage, researchers need to set up large clinical trials involving hundreds or maybe thousands of women. This can be difficult for a single research centre to achieve. Collaboration between centres is essential if we are to set up trials that can answer the big questions about miscarriage.

What’s happening in this project?

The PROMISE trial was the first ever miscarriage prevention trial to run on such a large scale. By bringing together doctors, academics, midwives, nurses and more, and involving more than 800 women in the UK and beyond, researchers were able to show for the first time that progesterone did not reduce the risk of another miscarriage in those who have suffered recurrent losses, despite smaller trials suggesting it may be effective.

We want to keep this momentum going in future trials. That’s why Tommy’s are maintaining this network so that it can be used to help researchers conduct large clinical trials of new treatments for miscarriage.

The Tommy’s national miscarriage trial platform now includes more than 90 hospitals across the UK. By connecting researchers from all over the country, the project is helping to make high-quality clinical trials possible. One such trial is MifeMiso, which has helped to identify the best treatment for women who have had a missed miscarriage and whose baby has not passed out of the womb naturally. Another key trial is PRISM, which has shown that treatment with progesterone should be recommended for women who have early pregnancy bleeding only if they have had one or more previous miscarriages.

What difference will this project make?

The Tommy’s national miscarriage trial platform is helping researchers to work together on high-quality clinical trials of new treatments for miscarriage. By doing this, we can influence international clinical practice and improve outcomes for women and their families. 

Thanks for your interest in our research

Tommy's funds research across the UK investigating the reasons for miscarriage, stillbirth and premature birth. We can keep you updated on ways you can support our work. If you would like to join our fight against baby loss and premature birth, click here.