Start: April 2017
End: April 2019
Why do we need this research?
Scientists supported by Tommy’s have been trying to understand how obesity during pregnancy affects children before and after birth. One common complication of obesity during pregnancy is gestational diabetes, which is normally treated with a drug called metformin. Researchers are now investigating whether metformin could reduce other risks linked to obesity during pregnancy, such as high birthweight.
Although metformin is safe to use during pregnancy, there is some evidence that it might increase the risk of obesity in children. We need to better understand the long-term effects of this commonly used drug for children.
What’s happening in this project?
A previous trial called EMPOWaR tested whether a drug called metformin could help obese women without diabetes to reduce their baby’s birthweight. The children born to the women who took part in the original EMPOWaR study are now about five years old. Researchers funded by Tommy’s have invited these women to take part in a follow-up study to understand what effects (if any) metformin has had on their child.
Our scientists have asked the women to fill out questionnaires about their child’s development, diet and exercise. The team also measured the children’s body composition (the amount of fat in their body), as well as their blood pressure and stiffness of their blood vessels. This is to understand if metformin might cause any heart or circulation problems.
The research team are now analysing all the data to confirm the effectives of metformin for these children.
What difference will this project make?
Metformin is frequently used during pregnancy to treat gestational diabetes. Previous work with the EMPOWaR study participants showed that taking metformin during pregnancy has no harmful effects on the placenta. This project will show whether or not there are any long-term effects for the children. The results will help doctors and parents understand the risks (if any) of metformin, allowing them to make informed choices about the treatment.
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Tommy's funds research across the UK investigating the reasons for pregnancy complications and loss. If you're interested in being kept updated about our research and news from Tommy's, click here.
A recently published article, co-authored by Professor Catherine Williamson from Tommy’s Research Centre at King’s College London, suggests that certain pregnancy complications can indicate future health issues for women.
Tommy’s has received a grant from the UK Government’s Department for Health and Social Care to support the costs of its PregnancyHub information and support services throughout the summer, due to rising demand in the wake of coronavirus.
Although recruitment to some clinical trials had to be paused when coronavirus hit the UK, scientists at Tommy’s Research Centres across the UK are still hard at work, supporting women and families in our specialist clinics and sharing their latest studies with academic journals.
The day before Mother’s Day, and two days before the UK officially went into coronavirus lockdown, Zara Dawson found out she was having a miscarriage. Her third consecutive miscarriage in less than a year, and fourth consecutive loss, after losing her second son Jesse in 2018 to termination for medical reasons.