Obese women are 3-6 times more likely to develop diabetes during pregnancy than women who have a healthy weight. Diabetes can hurt both mother and baby, and increases the likelihood of stillbirth and premature birth, as well as the risk of diabetes and obesity when the baby grows up. This means that it is vital to be able to tell early which women are more likely to develop diabetes during pregnancy. We can then try and stop it before it happens, or treat it as early as possible.
Studies like UPBEAT have tested if changing the diets and lifestyles of obese pregnant women could help lower the risk of diabetes. The results were unexpected: the risk of diabetes stayed the same. This means it is even more important to find out how and why some women get diabetes, while others don’t. We are looking for changes in certain “biomarkers” in the blood before and during diabetes in over 1,500 women who took part in UPBEAT. These could help us to understand how the disease works, and how to tell which women are most at risk.
'Biomarkers' are simply substances made by the body that can give us clues about how our bodies work. They are very useful for understanding disease: we can look for markers that are different in people who have a certain illness. Scientists can then use this information to help predict, and hopefully treat, the problem.
Over the last 12 months, researchers supported by Tommy’s have been looking at blood samples over the course of pregnancy from women in the UPBEAT trial. So far, they have found significant changes in blood samples from women who go on to develop diabetes compared to those who don’t.
We are now studying how the same markers change after diabetes has developed. Once this has finished, we will start looking at how the markers are affected by treating diabetes. The results from this study will give us important clues about why some obese women get diabetes during pregnancy, and hopefully help us to tell which women are more likely to suffer from it.
Professor Lucilla Poston, Dr Annette Briley, Dr Dharmintra Pasupathy, Mr Paul Seed, Dr Sara L White, the UPBEAT consortiumHide details
This study takes place in a Tommy's centre and is funded by Tommy's and the National Institute for Health Research, Chief Scientist Office Scotland, Guys' and St Thomas' Charity, Diabetes UK, and the Medical Research CouncilHide details