Looking at twins from pregnancy to childhood (the TWO study)

Dr Dharmintra Pasupathy, Professor Lucilla Poston, Professor Tim Spector, Dr Jordana Bell, Dr Caroline Knight, Dr Rachel Tribe

Studying twins helps us to work out the importance of genes and environmental influences on health and disease.

Women who are pregnant with twins have a higher risk of complications for both mother and babies compared with single-baby pregnancies. Studying twins helps us to work out the importance of genes and environmental influences on health and disease. In this study we will follow mothers, their partners and the twins through pregnancy and into early childhood.

We aim to look at how the mother’s natural micro-organisms (in the gut and skin, for example) affect the babies’ genes, micro-organisms, development and health. We will also study the growth and development of the twins in order to find factors during pregnancy that might lead to health problems. We will recruit 100 women (and their partners) with twins in their first or second trimester who are seen at St Thomas’s, and follow up the twins to 3 years of age, over a 6 year period. We will aim to continue with similar work to expand the database and to make possible assessment of rarer complications or conditions in twin pregnancies. 

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Funding

This study takes place in a Tommy's centre and is funded by Tommy's and the Chronic Disease Research Foundation

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