The GOT-IT trial – how effective is glyceryl trinitrate for a retained placenta?

Fiona Denison, Jane Norman, John Norrie, Gladys McPherson, Graham Scotland, Cynthia Clarkson, Mathilde Peace, Jane Brewin, Sheonagh Brook-Smith

Research taking place in a Tommy’s centre is helping to find out how to treat women with retained placentas without surgery.

When the placenta is not pushed out of the vagina after delivery – known as retained placenta – this can cause heavy bleeding. At the moment, nearly 11,000 women suffer from a retained placenta every year in the UK. The UK-wide GOT-IT trial wants to find a better way of treating women with this problem.

Currently, the only treatment is to remove the placenta in the operating theatre. This is invasive and traumatic for new mothers, as they are separated from their babies and placed under anaesthesia.

Research partly taking place in Tommy’s Edinburgh centre is looking at whether a substance called glyceryl trinitrate (GTN) could be used instead of surgery to treat women with a retained placenta.

Following a small pilot study, 1,106 women are taking part in the main trial, which has now expanded to 28 centres across the UK. We hope to present our results in March 2018.

Thanks for your interest in our research

Tommy's funds research across the UK investigating the reasons for pregnancy complications and loss. Maternal and fetal research is underfunded and we need your support to continue. There are many small and large ways you can support us, find out more here.


This study takes place in a Tommy's centre and is funded by the Health Technology Assessment Board

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