UPBEAT-TEMPO: does changing lifestyle during pregnancy affect children at age 3-4?

Professor Lucilla Poston, Dr Dharmintra Pasupathy, Mr Paul Seed, Dr Annette Briley, Dr Nashita Patel, Ms Claire Singh, Ms Angela Flynn, Mr Alex Ignatian, Clinical Research Network Midwives and research associates, the UPBEAT consortium

Researchers supported by Tommy’s are looking at children of the women who took part in the original UPBEAT trial to see what effects a change of lifestyle during pregnancy is having as their children grow up.

This research looks at the long-term effects of a baby’s early nutrition – from as early as in the womb – on their health later on. The UPBEAT study explored the effects on the baby of a low glycaemic index (GI) diet and more physical activity in obese women during pregnancy.

Over time, we want to find out whether improving a mother’s diet and lifestyle during pregnancy can stop babies from growing too large and storing too much fat as children. We will also be able to see whether children of mothers who changed their lifestyles have a lower risk of other illnesses such as diabetes when they grow up.

The UPBEAT-TEMPO study began in 2014 and looks at 3-4 year olds of women who took part in the original UPBEAT trial. From this, we will be able to see if children of women who changed their lifestyles during pregnancy are healthier than those who didn’t. More specifically, we will be looking for links between maternal diet, pregnancy weight gain and components of the cord blood with infant obesity.

In September 2017, we exceeded our recruitment target with 455 women and children now signed up to take part. 

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This study takes place in a Tommy's centre and is funded by Tommy's, EU EarlyNutrition, the Medical Research Council, and the National Institute for Health Research's Clinical Research Network

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