Around 60,000 babies are born too early every year in the UK. The OPPTIMUM trial was a double-blind randomised control trial that aimed to lower this number. It looked at whether giving progesterone to women at high risk of premature labour might prevent preterm births. Women took progesterone – a hormone that is naturally made by the body and helps maintain pregnancy – vaginally, every day between 22 and 34 weeks of pregnancy.
OPPTIMUM involved researchers from three of Tommy’s centres, and around 1,300 women from over 60 centres around the UK took part.
The study, which finished in 2015, showed that progesterone didn’t have any significant effect on decreasing the number of premature births. There was also no longer-term benefit to children after 2 years.
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This study took place in three of Tommy's centres and was funded by the Medical Research CouncilHide details