STOPPIT-2: can the Arabin pessary prevent premature birth in twin pregnancies?

Tommy’s Edinburgh centre is taking part in a national trial to see if a simple device can lower the risks of premature birth for twins.

Tommy’s Edinburgh research centre is taking part in the STOPPIT-2 trial: a national study looking at whether the Arabin pessary can stop premature birth in women pregnant with twins. In 2016, we had the best ever month for recruitment to the trial!

Women with a twin pregnancy are at a higher risk of going into early labour. The Arabin pessary is a small, cone-shaped device that is inserted through the vagina and surrounds the cervix, giving it support. This helps to keep the baby in the womb.

A large randomised trial has suggested that the pessary can reduce premature birth in women pregnant with one baby. Recently, a Dutch study has indicated that it may also work for twin pregnancies.

The STOPPIT-2 trial aims to find out for sure whether the Arabin pessary can help prevent premature birth of twins. Women with a twin pregnancy whose cervix is shorter than 35mm will be chosen at random to either receive the pessary, or standard treatment. The length of the cervix is important: if it gets too short, the risk of premature birth increases.

The pessary is cheap and easy to use, and if effective will have major health benefits across the world. 

I am interested in taking part in this trial


Professor Jane Norman, Professor Sarah Cunningham-Burley

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This study takes place in a Tommy's centre and is funded by the National Institute for Health Research's Health Technology Assessment programme

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