Start: September 2016
End: August 2019
Why do we need this research?
Fetal growth restriction (FGR) is when a baby grows slower than it should do in the womb. Babies whose growth slows or stops early on in pregnancy are at a much higher risk of stillbirth. In very early cases – before 28 weeks of pregnancy, when the baby weighs less than 600g – there is a very low chance of survival. This is known as extreme early-onset fetal growth restriction, or eFGR.
At the moment, there is almost no research on how to help women who have babies with eFGR. We don’t know how many people it affects, and different doctors respond to it in different ways, meaning it can be difficult to give good advice to parents of eFGR babies.
Parents can be faced with tough decisions if their baby is very small. It may be a choice between delivering the baby when there is a very slim chance of survival, or not intervening, in which case stillbirth is almost certain.
Tommy’s want to change this. We need to understand eFGR better in order to provide the best support to parents and determine how best to intervene to reduce risk of stillbirth.
What’s happening in this project?
Our researchers have been studying eFGR in various ways, and so far, they have made three important discoveries.
Firstly, by studying maternity data from NHS Scotland, involving 950 cases of eFGR, they have determined that eFGR occurs in 3 out of 1,000 pregnancies. The team are now using the same data to work out survival rates for eFGR babies, based upon their weight and time in the womb.
Secondly, our researchers have identified methods using ultrasound that could help determine how likely that an eFGR baby will be stillborn. Analysing ultrasound data from almost 200 cases of eFGR, they found that low weight, slow growth speed, and abnormal blood flow in the umbilical cord and uterus could be combined to help calculate the chances of stillbirth.
Finally, the team have found that the heartbeat of eFGR babies is different to that of babies who are growing normally. However, more research is needed to determine how to use this information to predict the outlook for eFGR babies.
What difference will this project make?
Our scientists hope that their discoveries could lead to better ways to predict the outlook for babies experiencing extreme early-onset fetal growth restriction. This will help us provide better information to parents at a difficult time. This research could also reveal how doctors can best intervene to reduce the risk of the baby dying
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Tommy's funds research across the UK investigating the reasons for pregnancy complications and loss. If you're interested in being kept updated about our research and news from Tommy's, click here.
More research projects
A recently published article, co-authored by Professor Catherine Williamson from Tommy’s Research Centre at King’s College London, suggests that certain pregnancy complications can indicate future health issues for women.
Tommy’s has received a grant from the UK Government’s Department for Health and Social Care to support the costs of its PregnancyHub information and support services throughout the summer, due to rising demand in the wake of coronavirus.
Although recruitment to some clinical trials had to be paused when coronavirus hit the UK, scientists at Tommy’s Research Centres across the UK are still hard at work, supporting women and families in our specialist clinics and sharing their latest studies with academic journals.
The day before Mother’s Day, and two days before the UK officially went into coronavirus lockdown, Zara Dawson found out she was having a miscarriage. Her third consecutive miscarriage in less than a year, and fourth consecutive loss, after losing her second son Jesse in 2018 to termination for medical reasons.