Start: March 2013
End: June 2019
This project is now complete.
Why do we need this research?
Pregnant women are encouraged to be aware if their baby is moving less than usual. This can sometimes be a sign that something is wrong and that the baby may need to be delivered early.
However, most women who report that their baby is moving less go on to have a normal healthy pregnancy and delivery. We need better ways to spot if babies are struggling, so that doctors can intervene early if needed.
What happened in this project?
Our scientists have been developing ways to spot pregnancy complications early on. A lot of pregnancy complications can be caused by problems with the placenta. Our researchers think a substance in the blood called Placental Growth Factor (PlGF) could be a useful to spot these problems early.
The team set up a small pilot trial to understand whether it was feasible to use a PlGF blood test to identify which pregnant mothers were the most in need of urgent care. Mothers who reported reduced fetal movements after 36 weeks of pregnancy were asked to participate, and 216 women were recruited to the trial. All the women had a blood test to measure levels of PlGF in the blood. Half the women were given standard care, and for the other half, the results of their blood test were acted upon – for example, by inducing labour or delivering early by Caesarean section.
The pilot study was successful, showing that it would be possible to conduct a large trial to study the impact of a PlGF blood test on pregnancy complications. A larger trial is needed to study this because the rates of pregnancy complications among the group of women studied was relatively low.
What difference will this project make?
This project lays the foundations for larger studies to investigate whether a simple blood test might help to spot pregnancy complications early. This could mean that women either get reassurance that their baby is healthy, or that they could get the urgent care they need to prevent stillbirth.
Get our research updates
Tommy's funds research across the UK investigating the reasons for pregnancy complications and loss. If you're interested in being kept updated about our research and news from Tommy's, click here.
Read more on this topic
We asked our lovely friend and supporter, Jennie Agg, what motherhood and Mother's Day means to her. In this piece, she speaks of her difficult past experiences of Mother's Day, how she has grappled with a sense of being in limbo, and the ultimate purity of her feeling of mother love.
In the lead up to Mother's Day, you might find yourself thinking about how to process your emotions and what to do on the day itself. The anticipation can often feel scary or daunting, and finding ways to look after yourself is important. In this blog, you'll find advice from a few of our lovely supporters who understand how you're feeling.
New research has revealed the benefits of giving progesterone to women with early pregnancy bleeding and a history of miscarriage.
Tommy’s spent yesterday morning at the charming Foundling Museum in London, celebrating the work of Tommy’s National Centre for Maternity Improvement alongside the opening of the museum’s new exhibition, ‘Portraying Pregnancy’.