Why do we need this research?
In India, 3.6 million pregnancies end in premature birth every year. This is almost a quarter of all premature births in the world. Many of these babies will die, and those that survive may be disabled. The problem is particularly severe in rural communities where access to healthcare is low, meaning that women can’t get the help they need. We cannot allow this to continue.
What’s happening in this project?
Tommy’s researchers are helping to test a cheap, easy-to-use method to tell how likely a woman is to give birth prematurely. The test measures the amount of progesterone, a hormone that helps maintain pregnancy, in samples of saliva from pregnant women. Early evidence from researchers in India, the UK and Egypt shows that this is a promising way of predicting premature birth.
Before introducing the test more widely, we need to see how well it works in large groups of women in rural communities, where access to healthcare is low. At the moment, there are no routine treatments from preterm birth in these communities: women at risk aren’t getting the care they need.
Our researchers recruited 2,000 pregnant women to take part in the trial, called PROMISES. All these women had an ultrasound scan to check how far along the baby is. The women donated a sample of saliva between 24-28 weeks of pregnancy, which were all sent to a laboratory to check the level of progesterone. The women were then monitored for the rest of their pregnancy to see when they give birth, and if there were any other complications. Our researchers are now analysing all the data from the study and will release the results soon.
What difference will this project make?
If the saliva test is successful, this could be a life-changing innovation for many women. The test is simple, non-invasive, and doesn’t need a skilled professional to carry it out. Women at risk of premature birth could be identified early, and given the care and support they need to give their baby the best chance of a healthy start in life.
Thanks for your interest in our research
Tommy's funds research across the UK investigating the reasons for miscarriage, stillbirth and premature birth. We can keep you updated on ways you can support our work. If you would like to join our fight against baby loss and premature birth, click here.
More research projects
New research has revealed the benefits of giving progesterone to women with early pregnancy bleeding and a history of miscarriage.
Tommy’s spent yesterday morning at the charming Foundling Museum in London, celebrating the work of Tommy’s National Centre for Maternity Improvement alongside the opening of the museum’s new exhibition, ‘Portraying Pregnancy’.
Miscarriage and ectopic pregnancy may trigger long-term post-traumatic stress, anxiety and depression
The largest ever study into the psychological impact of miscarriage and ectopic pregnancy has shown that early-stage pregnancy loss can have a serious impact on mental health. The research was led by Professor Tom Bourne at the Tommy’s National Centre for Miscarriage Research at Imperial College London.
A pilot trial led by Tommy’s National Centre for Miscarriage Research suggests diabetes drug could be repurposed to target the lining of the womb in women with recurrent miscarriage.