Understanding how blood sugar levels change during gestational diabetes

Rebecca Reynolds, Fiona Denison, Niamh McClennan

We have treatments for gestational diabetes, but they don’t always work well enough to prevent problems during pregnancy. In this project, our researchers are studying how blood sugar levels change throughout the day during early pregnancy. This will help us know how and when to intervene to treat gestational diabetes, and so prevent complications.

Start: 2020

End: 2023

Why do we need this research?

Mothers with gestational diabetes have too much sugar in their blood during pregnancy. It is a common problem which can result in problems such as the baby growing too fast in the womb.

We have treatments for gestational diabetes, including changes to diet and drugs like insulin and metformin. However, despite the best efforts of the mother and doctors, babies are still sometimes born too large. We need to better understand how the amount of sugar in the blood is controlled during pregnancy, and how this sugar is transferred to the baby.

What’s happening in this project?

In this project, researchers funded by Tommy’s are studying how blood sugar levels change during early pregnancy and how the placenta might be involved in controlling them. The team will recruit women with and without gestational diabetes to their study, and monitor blood sugar levels in detail to understand how they change during the day.

The team will also study the placenta in pregnant women using medical scans, and study samples of placenta in the lab donated by women after they have given birth. This will help them to understand how sugar is transferred from mother to baby, and how this might lead to babies growing too fast.

What difference will this project make?

Our researchers hope that their project will shed more light on how sugar levels can be controlled during gestational diabetes. This could ensure that doctors know how and when to intervene to treat the condition and reduce the chance of complications for mother and baby.

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