Why do we need this research?
As many as 1 in 4 women will have a miscarriage in their lifetime. However, we still don’t have effective ways to predict it or prevent it from happening.
In order to test new treatments to prevent miscarriage, researchers need to set up large clinical trials involved hundreds or maybe thousands of women. This can be difficult for any one research centre to achieve. Collaborations are needed to set up trials to answer the big questions about miscarriage.
What’s happening in this project?
The PROMISE trial was the first ever miscarriage prevention trial to run on such a large scale. It involved more than 800 women, in the UK and beyond, and brought together doctors, academics, midwives, nurses and more.
We want to keep this momentum going in future trials. That’s why Tommy’s are helping maintain this network for miscarriage research that will be used across the country to help researchers and patients.
The Tommy’s national miscarriage trial platform now includes more than 80 early pregnancy units across the UK. This collaboration is essential for other trials like SIMPLANT and SIM, and also helps studies which Tommy’s supports, such as the PRISM and TABLET trials. By helping to connect researchers all over the country, the project is helping to making more high-quality clinical trials possible.
What difference will this project make?
Our researchers are continuing to grow the network so that we can continue doing and sharing high quality research on a national scale. Through doing this, we can answer important questions about why miscarriage happens and how to stop it.
Thanks for your interest in our research
Tommy's funds research across the UK investigating the reasons for miscarriage, stillbirth and premature birth. We can keep you updated on ways you can support our work. If you would like to join our fight against baby loss and premature birth, click here.
Miscarriage and ectopic pregnancy may trigger long-term post-traumatic stress, anxiety and depression
The largest ever study into the psychological impact of miscarriage and ectopic pregnancy has shown that early-stage pregnancy loss can have a serious impact on mental health. The research was led by Professor Tom Bourne at the Tommy’s National Centre for Miscarriage Research at Imperial College London.
A pilot trial led by Tommy’s National Centre for Miscarriage Research suggests diabetes drug could be repurposed to target the lining of the womb in women with recurrent miscarriage.
More than a third of maternity doctors admitted they suffer from burnout and exhaustion. This means that they may avoid difficult cases, over-prescribe medications and care less about their patients, increasing the risk of mistakes.
Abdominal stitch is more effective than vaginal stitch for women who experience recurrent preterm births
A clinical trial has shown that an abdominal stitch can save babies’ lives by reducing preterm birth for high-risk women who have had a previous failed vaginal stitch. The trial was led and co-authored by Professor Andrew Shennan, Clinical Director of Tommy’s Preterm Surveillance Clinic.