Start: September 2012
End: December 2015
This project is now complete.
Why do we need this research?
As many as 1 in 4 women will experience a miscarriage in their lifetime. For many of these women, there is no explanation for why it happened to them, or whether they could have another miscarriage in the future. We need to better understand the causes of miscarriage so that we can predict who is most at risk, and find ways to prevent it from happening.
Chlamydia is a sexually transmitted infection which in most cases does not cause any symptoms, meaning most people would be unaware if they are carriers. Previous research has suggested that there may be a link between miscarriage and the chlamydia. However, we don’t know enough to be certain, so more research is needed to confirm or disprove this link.
What happened in this project?
Researchers supported by Tommy’s have been investigating the link between chlamydia and miscarriage in different ways.
Firstly, our researchers studied in the lab how chlamydia affects cells from the lining of the womb. The attachment of the embryo to the womb lining, and the development of the placenta, is a complex process which involves many factors. Their research has shown that chlamydia infection might affect this process, meaning that placenta don’t work as they should.
Secondly, our researchers investigated if a chlamydia infection has any effect on pregnant mice. However, they found that chlamydia infection does not increase the rate of miscarriage in these mice.
Finally, our researchers are studying the link between chlamydia infection and miscarriage in women. They are currently recruiting 600 women, 300 who have had a miscarriage and 300 who haven’t, to determine if there is any difference in the rates of chlamydia infection. This could provide evidence whether or not chlamydia increases risk of miscarriage.
What difference will this project make?
The lab experiments in this project have shown that the link between chlamydia and miscarriage is not clear-cut. In their study with women, the researchers hope to show for certain whether or not there is a link. If it is found that chlamydia can cause miscarriage, it would mean that the public can receive accurate information about the risks of chlamydia, and could mean that screening is made more widely available.
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More research projects
A recently published article, co-authored by Professor Catherine Williamson from Tommy’s Research Centre at King’s College London, suggests that certain pregnancy complications can indicate future health issues for women.
Tommy’s has received a grant from the UK Government’s Department for Health and Social Care to support the costs of its PregnancyHub information and support services throughout the summer, due to rising demand in the wake of coronavirus.
Although recruitment to some clinical trials had to be paused when coronavirus hit the UK, scientists at Tommy’s Research Centres across the UK are still hard at work, supporting women and families in our specialist clinics and sharing their latest studies with academic journals.
The day before Mother’s Day, and two days before the UK officially went into coronavirus lockdown, Zara Dawson found out she was having a miscarriage. Her third consecutive miscarriage in less than a year, and fourth consecutive loss, after losing her second son Jesse in 2018 to termination for medical reasons.