45 UK hospitals are now recruiting for the PRISM trial, which is looking to see if giving progesterone can prevent miscarriage in women with early pregnancy bleeding.
The PRISM project team, led by Tommy’s Dr Arri Coomarasamy, are recruiting women who have suffered miscarriages to join this research trial.
They are nearly halfway there with 2244 women signed up, but still need more volunteers to make this trial happen!
Who can take part?
The researchers are recruiting women who:
- are aged 16 – 39
- have an on-going pregnancy
- have experienced recent early pregnancy bleeding within the last four days during the first 12 weeks of pregnancy
- are willing to be selected at random to have either the treatment or a placebo, without knowing which they are given.
How does the trial work?
PRISM is a randomised, double-blind, placebo-controlled trial:
Randomised: The women who take part will be given either the treatment drug (progesterone) or a placebo – a dummy drug that has no active ingredients. A computer makes the selection so it’s completely random.
Double-blind: The women in the study won’t be told whether they are taking the active medicine or the placebo – and neither will their doctors. So both groups are blinded to this information.
Placebo-controlled: Half the women in the study will have the active medicine and half (the controls) will have the placebo. The medicine that they receive will look exactly the same to them and their doctors, but a completely separate group will keep a record of which women have progesterone and which have the placebo.
By doing the trial in this way, researchers will be able to conclusively test if progesterone has an affect on preventing early miscarriage.
Which centres are taking part?
- Airedale General Hospital
- Birmingham Heartlands Hospital
- Birmingham Women's Hospital
- Bradford Royal Infirmary
- Burnley General Hospital
- Chelsea and Westminster Hospital
- Cumberland Infirmary, Carlisle
- Derriford Hospital, Plymouth
- Glasgow Royal Infirmary
- East Surrey Hospital
- Hinchingbrooke Hospital, Huntingdon
- Hull Royal Infirmary
- James Cook University Hospital, Middlesbrough
- John Radcliffe Hospital, Oxford
- Kings College Hospital
- Liverpool Women's Hospital
- Musgrove Park Hospital, Taunton
- New Cross Hospital, Wolverhampton
- North Devon District Hospital
- Princess Royal Hospital, Telford
- Queen Alexandra Hospital, Portsmouth
- Queen's Hospital, Burton
- Queen's Medical Centre, Nottingham
- Royal Stoke University Hospital
- Royal Victoria Infirmary, Newcastle
- Royal Preston Hospital
- Royal Devon and Exeter Hospital
- Royal Infirmary of Edinburgh
- Scunthorpe General Hospital
- St. James' University Hospital, Leeds
- Sheffield Royal Hallamshire Hospital
- St. Mary's Hospital, London
- St. Mary's Hospital, Manchester
- St. Michael’s University Hospital, Bristol
- St. Peter's Hospital, Chertsey
- St. Thomas's Hospital, London
- Sunderland Royal Hospital
- University College London Hospital
- University Hospital Coventry
- Walsall Manor Hospital
- Warrington Hospital
- West Middlesex University Hospital
- Whipps Cross University Hospital
- Whiston Hospital
- Worcester Royal Hospital
I want to take part or have further questions – what should I do next?
If you want to chat about any aspect of taking part in the trial please contact the trial co-ordinating centre:
Trial Co-ordinator: Adam Devall
Telephone: 0121 414 9011
Email: [email protected]
Professor Arri Coomarasamy, Director of Tommy’s National Centre for Miscarriage Research, at the University of Birmingham:
"Miscarriage is a common but deeply personal and often isolating experience for many couples. At the new Tommy's National Centre for Miscarriage Research, we are determined to make a difference. We are committed to understand the causes of miscarriage and find ways to prevent it. Tommy's investment in the new Centre is the best thing that has happened to miscarriage research. It will change many lives."
To read more about the trial at the official PRISM website, click here:
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